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• Drug design
  ... important case study in rational drug design is [[imatinib]], a [[tyrosine kinase]] inhibitor designed specifically for the ''bcr-abl'' fusion protein that ...
  6 KB (827 words) - 06:06, 17 September 2008
• RNAi
  ... pathways, some of which can lead to apoptosis. The dsRNA-dependent protein kinase (PKR) is an important antiviral detector protein and is activated by bindi ...
  21 KB (3143 words) - 10:35, 9 September 2008
• Protein-protein interaction
  ... act briefly with another protein just to modify it (for example, a protein kinase will add a phosphate to a target protein). This modification of proteins c ...
  12 KB (1655 words) - 09:01, 12 September 2008
• Chemogenomics
  ... robes to investigate their action on specific target classes, e.g., GPCRs, kinases, low-affinity inhibitors into larger analogs and to construct certain kinase
  4 KB (574 words) - 06:17, 17 September 2008
• Colchicine
  ... d cause weakness in patients with impaired kidney function; serum creatine kinase may be elevated. Usually resolves in 3 to 4 wk after drug withdrawal.
  4 KB (578 words) - 05:49, 23 April 2009
• Aldosterone
  ... > pumps]] and their regulatory proteins [[serum and glucocorticoid-induced kinase]], and [[channel-inducing factor]] respectively.
  17 KB (2332 words) - 11:48, 19 February 2009
• Serotonin
  ... vation and stimulates phosphorylation of p44/p42 mitogen-activated protein kinase activation in bovine aortic endothelial cell cultures.<ref>{{Cite journal ... tryptamine stimulates phosphorylation of p44/p42 mitogen-activated protein kinase activation in bovine aortic endothelial cell cultures
  38 KB (5178 words) - 12:28, 19 February 2009
• Epinephrine
  ... ay]], signaling the phosphorylation of glycogen synthase and phosphorylase kinase (inactivating and activating them, respectively), leading to the latter ac ...
  16 KB (2097 words) - 12:32, 19 February 2009
• 5-OXO-ETE
  This is important in MAP kinase,cPLA2,PI 3-Kinase siganal transduction pathways.
  497 B (68 words) - 03:48, 11 November 2008
• Bisphenol A
  ... title = Ontogeny of rapid estrogen-mediated extracellular signal-regulated kinase signaling in the rat cerebellar cortex: potent nongenomic agonist and endo ...
  48 KB (6845 words) - 04:51, 20 February 2009
• Genistein
  ... HASE arrest in human and murine cell lines and inhibits PROTEIN-TYROSINE KINASE. ... ein's chief method of activity is as a tyrosine kinase inhibitor. Tyrosine kinases are less widespread than their ser/thr counterparts but implicated in alm ...
  11 KB (1547 words) - 09:12, 19 February 2009
• Prostacyclin
  ... ntinues the cascade by phosphorylating and inhibiting [[myosin light-chain kinase]] which leads to [[smooth muscle]] relaxation and [[vasodilation]]. Notabl ...
  8 KB (1096 words) - 09:52, 20 February 2009
• Glucagon
  ... P-dependent protein kinase). This enzyme in turn activates [[phosphorylase kinase]], which in turn, phosphorylates [[glycogen phosphorylase]], converting in ...
  12 KB (1655 words) - 08:05, 17 February 2009
• Gonadoliberin-1
  ... ide phospholipase C]], which goes on to mobilize [[calcium]] and [[protein kinase C]]. This results in the activation of proteins involved in the synthesis ...
  12 KB (1557 words) - 06:45, 11 December 2009
• Ghrelin
  ... form]] of [[nitric oxide synthase]] in a pathway that depends on various [[kinase]]s including [[Akt]].{{Fact|date=August 2008}}
  18 KB (2520 words) - 08:03, 17 February 2009
• Prolactin
  ... sults in the activation of [[mitogen-activated protein kinases]] and [[Src kinase]]. <ref name=Mancini2008/>
  13 KB (1795 words) - 08:18, 17 February 2009
• 5-hydroxytryptamine 2A receptor
  ... nd [[inositol triphosphate]]&nbsp;(IP3), which in turn stimulate [[protein kinase C]]&nbsp;(PKC) activity and [[Ca2+|Ca²⁺]] release.<ref name="pm ... ... LA2]] activity, activation of [[PLD]], [[Rho family of GTPases|Rho]]/[[Rho kinase]], and [[ERK]] pathway activation initiated by agonist stimulation of the ...
  15 KB (2022 words) - 09:07, 14 December 2009
• Insulin receptor precursor7101)
  ... t is activated by [[insulin]]. It belongs to the large class of [[tyrosine kinase receptors]]. [[Tyrosine kinase receptors]], including the '''insulin receptor''', mediate their activity ...
  9 KB (1151 words) - 09:33, 16 December 2009
• COLCHICINE DERIV
  ... ation includes a progressive onset of proximal weakness, elevated creatine kinase, and sensorimotor polyneuropathy. Colchicine toxicity can be potentiated b ...
  9 KB (1308 words) - 06:25, 23 April 2009
• Anti-Muellerian hormone type-2 receptor precursor71130)(Anti-Muellerian hormone type II receptor)
  ... Ser/Thr protein kinase family. TGFB receptor subfamily. Contains 1 protein kinase domain. ... ex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which auto ...
  848 B (97 words) - 05:52, 15 December 2009

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