5-OXO-ETE

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5-OXO-ETE Pubchem(5283159)

RN given is for cpd without isomeric designation; an arachidonate metabolite which stimulates neutrophils to mobilize Ca and promotes PMN degranulation responses.

KEGG Pathway(C14732)

  • Arachidonic acid metabolism

Ec50=4nM2

This is important in MAP kinase,cPLA2,PI 3-Kinase siganal transduction pathways. The 5oxo-ETE receptor belong to the g-protein coupled receptor family as the action of this substance are blocked by the G-protein inhibitor pertusis toxin.

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