Palmatine chloride hydrate

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Palmatine chloride hydrate
Systematic (IUPAC) name
2,3,9,10-tetramethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-iumchloride hydrate
Identifiers
CAS number	?
ATC code	?
PubChem	16212317
Chemical data
Formula	C21H24ClNO5
Mol. mass	405.87196
SMILES	eMolecules & PubChem
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	?

[edit] Description

Palmatine is a protoberberine alkaloid isolated from medicinal herbs such as Coptis chinensis. It is a selective toposomerase I and II poison. The sedative effect of palmatine is related to its ability to inhibit dopamine biosynthesis. Palmatine is a vasodilator that reduces [Ca2+].

[edit] General Properties

*Molecular Weight

405.87196

*Molecular Formula

C₂₁H₂₄ClNO₅

*IUPAC NAME

2,3,9,10-tetramethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-iumchloride hydrate

*Canonical Smiles

COC1=C(C2=C[N+]3=C(C=C2C=C1)C4=CC(=C(C=C4CC3)OC)OC)OC.O.[Cl-]

*Isomeric Smiles

N/A

*XLogP

N/A

*Topological Polar Surface Area

41.8

[edit] External Links

• Pubchem

Link to BIAdb Database