18-hydroxycorticosterone

From DrugPedia: A Wikipedia for Drug discovery

18-hydroxycorticosterone
Systematic (IUPAC) name
(8S,9S,10R,11S,13R,14S,17S)-11-hydroxy-17-(2-hydroxyacetyl)-13-(hydroxymethyl)-10-methyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
Identifiers
CAS number	561-65-9
ATC code	?
PubChem	11222
Chemical data
Formula	C21H30O5
Mol. mass	362.46
SMILES	eMolecules & PubChem
Synonyms	11beta,18,21-Trihydroxypregn-4-ene-3,20-dione
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	?

Show 3-D Structure

[edit] Description

18-Hydroxycorticosterone is a derivative of corticosterone.

It serves as an intermediate in the synthesis of aldosterone by the enzyme aldosterone synthase in the zona glomerulosa:

[edit] General Properties

*Molecular Weight

362.46

*Molecular Formula

C₂₁H₃₀O₅

*IUPAC NAME

(8S,9S,10R,11S,13R,14S,17S)-11-hydroxy-17-(2-hydroxyacetyl)-13-(hydroxymethyl)-10-methyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one

*Canonical Smiles

CC12CCC(=O)C=C1CCC3C2C(CC4(C3CCC4C(=O)CO)CO)O

*Isomeric Smiles

C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2[C@H](C[C@]4([C@H]3CC[C@@H]4C(=O)CO)CO)O

[edit] External Links

• [1]Pubchem
• [2]]KEGG Compound
• [3]Human Metabolome DataBase