Corticosterone
From DrugPedia: A Wikipedia for Drug discovery
| Corticosterone
| |
| Systematic (IUPAC) name | |
| (8S,9S,10R,11S,13S,14S,17S)-11-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one | |
| Identifiers | |
| CAS number | |
| ATC code | ? |
| PubChem | |
| Chemical data | |
| Formula | C21H30O4 |
| Mol. mass | 346.46 |
| SMILES | & |
| Synonyms | 17-Deoxycortisol |
| Physical data | |
| Melt. point | 181 °C |
| Solubility in water | 199 mg/L at 25oC EXP mg/mL |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | ? |
| Half life | ? |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
? |
| Legal status | |
| Routes | ? |
An adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid. (From Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1437).Corticosterone is a 21 carbon steroid hormone of the corticosteroid type produced in the cortex of the adrenal glands.
Contents |
[edit] Physiochemical Properties
[edit] Melting Point
181 deg C EXP
[edit] log P
1.94
[edit] Water Solubility=
199 mg/L 25 EXP
[edit] Vapor Pressure
4.74E-12 mm Hg 25 EST
[edit] Henry's Law Constant
3.70E-10 atm-m3/mole 25 EST
[edit] Atmospheric OH Rate Constant
1.16E-10 cm3/molecule-sec 25 EST
[edit] Roles
In many species, including rodents, corticosterone is the principal glucocorticoid, involved in regulation of fuel metabolism, immune reactions, and stress responses.
However, in humans, corticosterone is produced primarily in the zona fasciculata of the adrenal cortex. It has only weak glucocorticoid and mineralocorticoid potencies in humans and is important mainly as an intermediate in the steroidogenic pathway from pregnenolone to aldosterone. Corticosterone is converted to aldosterone by aldosterone synthase, found only in the mitochondria of glomerulosa cells. Glomerulosa cells are found in the Zona glomerulosa, which is the most superficial region of endocrine cells in the adrenal cortex.
[edit] Release or generation mechanisms
One example of a release pathway relates to UV-B stimulation on the skins of certain amphibians such as the Rough-skinned Newt, Taricha granulosa; this trigger seems to cause the internal generation of corticosterone in that species.<ref>C.M. Hogan, 2008</ref>
[edit] References
- C. Michael Hogan (2008) Rough-skinned Newt (Taricha granulosa), Globaltwitcher, ed. Nicklas Stromberg [1]
- Etienne-Emile Baulieu and Paul A. Kelly (1990) Hormones: From Molecules to Disease, Published by Springer Science & Business, 697 pages, ISBN 2705660305, 9782705660307
