Corticosterone
From DrugPedia: A Wikipedia for Drug discovery
CORTICOSTERONE Pubchem(5753)
An adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid. (From Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1437).Corticosterone is a 21 carbon steroid hormone of the corticosteroid type produced in the cortex of the adrenal glands.
KEGG Pathway(C02140)
- C21-Steroid hormone metabolism
| MMDB ID | PDB ID | Reference |
|---|---|---|
| 33346 | 1Y5R | Zhang J, Osslund TD, Plant MH, Clogston CL, Nybo RE, Xiong F, Delaney JM, Jordan SRCrystal structure of murine 11 beta-hydroxysteroid dehydrogenase 1: an important therapeutic target for diabetesBiochemistry v44, p.6948-6957 |
| Physical Property | Value | Units | Temp (deg C) | Source |
|---|---|---|---|---|
| Melting Point | 181 | deg C | EXP | |
| log P (octanol-water) | 1.94 | (none) | EXP | |
| Water Solubility | 199 | mg/L | 25 | EXP |
| Vapor Pressure | 4.74E-12 | mm Hg | 25 | EST |
| Henry's Law Constant | 3.70E-10 | atm-m3/mole | 25 | EST |
| Atmospheric OH Rate Constant | 1.16E-10 | cm3/molecule-sec | 25 | EST |
Functions
In many species, including rodents, corticosterone is the principal glucocorticoid, involved in regulation of fuel metabolism, immune reactions, and stress responses.
However, in humans, corticosterone is produced primarily in the zona fasciculata of the adrenal cortex. It has only weak glucocorticoid and mineralocorticoid potencies in humans and is important mainly as an intermediate in the steroidogenic pathway from pregnenolone to aldosterone. Corticosterone is converted to aldosterone by aldosterone synthase, found only in the mitochondria of glomerulosa cells. Glomerulosa cells are found in the Zona glomerulosa, which is the most superficial region of endocrine cells in the adrenal cortex.
