Cholecystokinin-22

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Description 2 Source Organism 3 Taxomomy 4 Subcellular Localization 5 Developmental Stage 6 Similarity 7 Post translational Modification 8 Function 9 GeneID

Description

Cholecystokinins precursor (CCK) [Contains: Cholecystokinin 39(CCK39); Cholecystokinin 33 (CCK33); Cholecystokinin 22 (CCK22);Cholecystokinin 12 (CCK12); Cholecystokinin 8 (CCK8)].

Source Organism

Rattus norvegicus (Rat).

Taxomomy

Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Rattus.

Subcellular Localization

Secreted.

Developmental Stage

Similarity

Belongs to the gastrin/cholecystokinin family.

Post translational Modification

Cholecystokinin, also known as CCK58, is proteolytically cleaved to produce a number of active cholecystokinins. Sulfation of Tyr-97 is essential for receptor activation.

Function

This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion

GeneID

25298

Categories:Hormones