Cholecystokinin-22

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Description 2 Source Organism 3 Taxomomy 4 Subcellular Localization 5 Developmental Stage 6 Similarity 7 Post translational Modification 8 Function 9 GeneID

[edit] Description

Cholecystokinins precursor (CCK) [Contains: Cholecystokinin 39(CCK39); Cholecystokinin 33 (CCK33); Cholecystokinin 22 (CCK22);Cholecystokinin 12 (CCK12); Cholecystokinin 8 (CCK8)].

[edit] Source Organism

Rattus norvegicus (Rat).

[edit] Taxomomy

Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Rattus.

[edit] Subcellular Localization

Secreted.

[edit] Developmental Stage

[edit] Similarity

Belongs to the gastrin/cholecystokinin family.

[edit] Post translational Modification

Cholecystokinin, also known as CCK58, is proteolytically cleaved to produce a number of active cholecystokinins. Sulfation of Tyr-97 is essential for receptor activation.

[edit] Function

This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion

[edit] GeneID

25298