V-erbA oncogene; Fragment
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Contents |
Source Organism
Avian erythroblastosis virus (strain ES4).
Taxomomy
Viruses; Retro-transcribing viruses; Retroviridae; Orthoretrovirinae;Alpharetrovirus.
Subcellular Localization
Nucleus (By similarity).
Developmental Stage
Similarity
Belongs to the nuclear hormone receptor family. NR1 subfamily. Contains 1 nuclear receptor DNA-binding domain.
Post translational Modification
Function
Acts as a thyroid-hormone receptor antagonist. The v- ErbA oncogene cooperates with v-ErbB and other primarily sarcoma- inducing oncogenes in transformation of erythroblasts. It is non transforming by itself and cannot induce self-renewal of erythroblasts. Instead it blocks the residual capacity of the v- ErbB cells to differentiate terminally.
