V-erbA oncogene; Fragment

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Contents 1 Source Organism 2 Taxomomy 3 Subcellular Localization 4 Developmental Stage 5 Similarity 6 Post translational Modification 7 Function

[edit] Source Organism

Avian erythroblastosis virus (strain ES4).

[edit] Taxomomy

Viruses; Retro-transcribing viruses; Retroviridae; Orthoretrovirinae;Alpharetrovirus.

[edit] Subcellular Localization

Nucleus (By similarity).

[edit] Developmental Stage

[edit] Similarity

Belongs to the nuclear hormone receptor family. NR1 subfamily. Contains 1 nuclear receptor DNA-binding domain.

[edit] Post translational Modification

[edit] Function

Acts as a thyroid-hormone receptor antagonist. The v- ErbA oncogene cooperates with v-ErbB and other primarily sarcoma- inducing oncogenes in transformation of erythroblasts. It is non transforming by itself and cannot induce self-renewal of erythroblasts. Instead it blocks the residual capacity of the v- ErbB cells to differentiate terminally.