Nuclear receptor subfamily 2 group B member 1
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Revision as of 00:00, 15 January 2001 by Special:Contributions/ (Talk)
Contents |
Source Organism
Homo sapiens (Human).
Taxomomy
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo.
Subcellular Localization
Nucleus.
Developmental Stage
Similarity
Belongs to the nuclear hormone receptor family. NR2 subfamily. Contains 1 nuclear receptor DNA-binding domain.
Post translational Modification
Sumoylated on Lys-108; which negatively regulates transcriptional activity. Desumoylated specifically by SENP6.
Function
Nuclear hormone receptor. Involved in the retinoic acid response pathway. Binds 9-cis retinoic acid (9C-RA). ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer (By similarity).
