Nuclear receptor subfamily 2 group B member 1

From DrugPedia: A Wikipedia for Drug discovery

Jump to: navigation, search

Contents

[edit] Source Organism

Homo sapiens (Human).

[edit] Taxomomy

Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo.

[edit] Subcellular Localization

Nucleus.

[edit] Developmental Stage

[edit] Similarity

Belongs to the nuclear hormone receptor family. NR2 subfamily. Contains 1 nuclear receptor DNA-binding domain.

[edit] Post translational Modification

Sumoylated on Lys-108; which negatively regulates transcriptional activity. Desumoylated specifically by SENP6.

[edit] Function

Nuclear hormone receptor. Involved in the retinoic acid response pathway. Binds 9-cis retinoic acid (9C-RA). ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer (By similarity).

Retrieved from "http://277988.efsst.group/drugpedia/index.php/Nuclear_receptor_subfamily_2_group_B_member_1"