20-alpha-dihydroprogesterone

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Dihydrogesterone Pubchem(8956)

A biologically active 20-alpha-reduced metabolite of PROGESTERONE. It is converted from progesterone to 20-alpha-hydroxypregn-4-en-3-one by the 20-ALPHA-HYDROXYSTEROID DEHYDROGENASE in the CORPUS LUTEUM and the PLACENTA.

KEGG Pathway(C04042,C03965)

  • C21-Steroid hormone metabolism
List of PDB files having estriol as a Ligand:
MMDB ID PDB ID Reference
24630 1MRQ Couture JF, Legrand P, Cantin L, Luu-The V, Labrie F, Breton RHuman 20alpha-hydroxysteroid dehydrogenase: crystallographic and site-directed mutagenesis studies lead to the identification of an alternative binding site for C21-steroidsJ. Mol. Biol. v331, p.593-604
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