PolysacDB Glucurunoxylomannan 2636

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

[edit] Carbohydrate Name

Glucurunoxylomannan

[edit] Carbohydrate Class

Miscellaneous

[edit] Source Microbe

Cryptococcus neoformans Serotype A

[edit] Basic Structure

A linear α(1-->3)- linked mannan backbone singly substituted with non-reducing β(1-->2) xylose and β(1-->2) glucuronic acid side branches ; O-acetyl groups are present at C-6 of the mannosyl residues

[edit] Proposed functions

Antiphagocytic ; an important virulence factor

[edit] Antigenic Nature used to produce antibodies

Glycoconjugates

[edit] Carrier Name

Tetanus toxoid

[edit] Conjugation Method

Conjugated using CDAP chemistry

[edit] Antibodies

Mab 13F1

[edit] Antibody type and class

IgM

[edit] Assay System

ELISA

[edit] Cross-reactivity

This antibody cross-reacted with Serotype A,B,C and D serotypes

[edit] Proposed epitopes

This Mab did not bind de-O-acetylated GXM suggesting that acetylated residues form an important part of the epitope

[edit] Proposed Utility

This antibody was used to decipher and differentiate the serum antibody response of autoimmune mice as compared to normal mice

[edit] Weblink

PubMed

[edit] External Links

• BCSDB Structural Detail

• IEDB Epitopic Detail

• Link to PolysacDB database