PolysacDB Glucurunoxylomannan 2636
From DrugPedia: A Wikipedia for Drug discovery
[edit] Carbohydrate Name
Glucurunoxylomannan
[edit] Carbohydrate Class
Miscellaneous
[edit] Source Microbe
Cryptococcus neoformans Serotype A
[edit] Basic Structure
A linear α(1-->3)- linked mannan backbone singly substituted with non-reducing β(1-->2) xylose and β(1-->2) glucuronic acid side branches ; O-acetyl groups are present at C-6 of the mannosyl residues
[edit] Proposed functions
Antiphagocytic ; an important virulence factor
[edit] Antigenic Nature used to produce antibodies
Glycoconjugates
[edit] Carrier Name
Tetanus toxoid
[edit] Conjugation Method
Conjugated using CDAP chemistry
[edit] Antibodies
Mab 13F1
[edit] Antibody type and class
IgM
[edit] Assay System
ELISA
[edit] Cross-reactivity
This antibody cross-reacted with Serotype A,B,C and D serotypes
[edit] Proposed epitopes
This Mab did not bind de-O-acetylated GXM suggesting that acetylated residues form an important part of the epitope
[edit] Proposed Utility
This antibody was used to decipher and differentiate the serum antibody response of autoimmune mice as compared to normal mice
