PolysacDB Lipopolysaccharide 2442
From DrugPedia: A Wikipedia for Drug discovery
Carbohydrate Name
Lipopolysaccharide
Carbohydrate Class
Lipopolysaccharide
Source Microbe
Shigella flexneri serotype Y
Basic Structure
LPS is a complex macromolecule composed of the biologically active lipid A moiety, covalently attached core oligosaccharide, and distally linked polysaccharide O-side chain. The O-antigen part consists of the following residues : -3)-α-D-GlcpNAc-(1-->3)-β-L-Rhap-(1-->2)-α-L-Rhap-(1-->2)-β-L-Rhap-(1-
Proposed functions
LPS plays an important virulence role based on its antiphagocytic and endotoxic properties
Antigenic Nature used to produce antibodies
Phenol killed cells
Carrier Name
nil
Conjugation Method
nil
Antibodies
Mab Y-B2
Antibody type and class
IgG3
Assay System
ELISA, immunodiffusion
Cross-reactivity
This Mab cross-reacted with 1a and 4a LPS
Proposed epitopes
This Mab reacted with alkali-treated LPS and O-antigen. Mab Y-B2 exhibits distinct preference for the oligosaccharide α-L-Rha(1-->2)α-L-Rha(1-->3)α-L-Rha(1-->3)βGlcNac repeating as a dimer
Proposed Utility
This Mab can be used for antigenic characterization of Shigella LPS
