PolysacDB Lipopolysaccharide 2442

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1 Carbohydrate Name
2 Carbohydrate Class
3 Source Microbe
4 Basic Structure
5 Proposed functions
6 Antigenic Nature used to produce antibodies
7 Carrier Name
8 Conjugation Method
9 Antibodies
10 Antibody type and class
11 Assay System
12 Cross-reactivity
13 Proposed epitopes
14 Proposed Utility
15 Weblink
16 External Links

[edit] Carbohydrate Name

Lipopolysaccharide

[edit] Carbohydrate Class

Lipopolysaccharide

[edit] Source Microbe

Shigella flexneri serotype Y

[edit] Basic Structure

LPS is a complex macromolecule composed of the biologically active lipid A moiety, covalently attached core oligosaccharide, and distally linked polysaccharide O-side chain. The O-antigen part consists of the following residues : -3)-α-D-GlcpNAc-(1-->3)-β-L-Rhap-(1-->2)-α-L-Rhap-(1-->2)-β-L-Rhap-(1-

[edit] Proposed functions

LPS plays an important virulence role based on its antiphagocytic and endotoxic properties

[edit] Antigenic Nature used to produce antibodies

Phenol killed cells

[edit] Carrier Name

nil

[edit] Conjugation Method

nil

[edit] Antibodies

Mab Y-B2

[edit] Antibody type and class

IgG3

[edit] Assay System

ELISA, immunodiffusion

[edit] Cross-reactivity

This Mab cross-reacted with 1a and 4a LPS

[edit] Proposed epitopes

This Mab reacted with alkali-treated LPS and O-antigen. Mab Y-B2 exhibits distinct preference for the oligosaccharide α-L-Rha(1-->2)α-L-Rha(1-->3)α-L-Rha(1-->3)βGlcNac repeating as a dimer