PolysacDB Lipoteichoic acids (LTAs) 2404

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

Carbohydrate Name

Lipoteichoic acids (LTAs)

Carbohydrate Class

Miscellaneous

Source Microbe

Streptococcus faecium 9790

Basic Structure

LTAs are amphiphiles composed of a membrane lipid or glycolipid which is covalently linked to a linear chain of 15 to 30 polyglycerophosphate (PGP) units

Proposed functions

Lipoteichoic acids (LTAs) are present on the surfaces of a majority of gram-positive bacteria and have been shown to constitute 1 to 2% of the dry weight of several organisms

Antigenic Nature used to produce antibodies

LTA preparation of S. faecium 9790.

Carrier Name

nil

Conjugation Method

nil

Antibodies

Mab 13G5

Antibody type and class

IgM

Assay System

Haemagglutination

Cross-reactivity

This MAbs agglutinated SRBCs sensitized with S. faecium LTA but failed to agglutinate SRBCs sensitized with the LTAs from the other bacterial species

Proposed epitopes

This MAb was thought to be specific for the kojibiosyl substituents (glucose α-1-->2 glucose) present on the LTA of group D streptococci

Proposed Utility

the anti-kojibiosyl MAbs would be useful as a specific reagent for identifying group D streptococci

Weblink

PubMed Central

External Links

• Link to PolysacDB database