PolysacDB Lipoteichoic acids (LTAs) 2404
From DrugPedia: A Wikipedia for Drug discovery
[edit] Carbohydrate Name
Lipoteichoic acids (LTAs)
[edit] Carbohydrate Class
Miscellaneous
[edit] Source Microbe
Streptococcus faecium 9790
[edit] Basic Structure
LTAs are amphiphiles composed of a membrane lipid or glycolipid which is covalently linked to a linear chain of 15 to 30 polyglycerophosphate (PGP) units
[edit] Proposed functions
Lipoteichoic acids (LTAs) are present on the surfaces of a majority of gram-positive bacteria and have been shown to constitute 1 to 2% of the dry weight of several organisms
[edit] Antigenic Nature used to produce antibodies
LTA preparation of S. faecium 9790.
[edit] Carrier Name
nil
[edit] Conjugation Method
nil
[edit] Antibodies
Mab 13G5
[edit] Antibody type and class
IgM
[edit] Assay System
Haemagglutination
[edit] Cross-reactivity
This MAbs agglutinated SRBCs sensitized with S. faecium LTA but failed to agglutinate SRBCs sensitized with the LTAs from the other bacterial species
[edit] Proposed epitopes
This MAb was thought to be specific for the kojibiosyl substituents (glucose α-1-->2 glucose) present on the LTA of group D streptococci
[edit] Proposed Utility
the anti-kojibiosyl MAbs would be useful as a specific reagent for identifying group D streptococci
