Corticosterone

From DrugPedia: A Wikipedia for Drug discovery

CORTICOSTERONE Pubchem(5753)

An adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid. (From Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1437)

KEGG Pathway(C02140) C21-Steroid hormone metabolism

MMDB ID: 33346 PDB ID: 1Y5R Reference: Zhang J, Osslund TD, Plant MH, Clogston CL, Nybo RE, Xiong F, Delaney JM, Jordan SRCrystal structure of murine 11 beta-hydroxysteroid dehydrogenase 1: an important therapeutic target for diabetesBiochemistry v44, p.6948-6957 11Beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) catalyzes the conversion of 11-dehydrocorticosterone to its active form corticosterone in rodents (or cortisone to cortisol in humans). The reductive reaction of the 11-keto to 11-hydroxyl is the pivotal switch in the activation of glucocorticoids. An excess of active glucocorticoids has been shown to play a key role in metabolic disorders such as diabetes and obesity....

Physical Property Value Units Temp (deg C) Source Melting Point 181 deg C EXP log P (octanol-water) 1.94 (none) EXP Water Solubility 199 mg/L 25 EXP Vapor Pressure 4.74E-12 mm Hg 25 EST Henry's Law Constant 3.70E-10 atm-m3/mole 25 EST Atmospheric OH Rate Constant 1.16E-10 cm3/molecule-sec 25