PolysacDB Y O-polysaccharide 2265

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

[edit] Carbohydrate Name

Y O-polysaccharide

[edit] Carbohydrate Class

O-polysaccharide [LPS]

[edit] Source Microbe

Shigella flexneri

[edit] Basic Structure

The O-LPS consists of a tetrasaccharide repeating unit α-L-Rhap-(1-->2)-α-L-Rhap(1-->3)- . This tetrasaccharide is polymerized and joined by β-1,2 linkages between N-acetyl-D-glucosamine and L-rhamnosyl to form the O-polysaccharide chain

[edit] Proposed functions

N/A

[edit] Antigenic Nature used to produce antibodies

heat-killed S. flexnerf bacteria serotype Y

[edit] Carrier Name

nil

[edit] Conjugation Method

nil

[edit] Antibodies

Mab MASF Y-1

[edit] Antibody type and class

N/A

[edit] Assay System

ELISA, FARR assay

[edit] Cross-reactivity

This Mab bound only to LPS of serotypes 4a and Y. In the glycoconjugate ELISA, MASF Y-1 bound only to the octasaccharide-(cdabcdab') and the decasaccharide-(abcdabcdab') BSA conjugate

[edit] Proposed epitopes

This Mab bound to intrachain determinants

[edit] Proposed Utility

This Mab would help in the delineation of the antigenic stucture of Y O polysaccharide

[edit] Weblink

PubMed

[edit] External Links

• IEDB Epitopic Detail

• Link to PolysacDB database