PolysacDB Y O-polysaccharide 2265
From DrugPedia: A Wikipedia for Drug discovery
[edit] Carbohydrate Name
Y O-polysaccharide
[edit] Carbohydrate Class
O-polysaccharide [LPS]
[edit] Source Microbe
Shigella flexneri
[edit] Basic Structure
The O-LPS consists of a tetrasaccharide repeating unit α-L-Rhap-(1-->2)-α-L-Rhap(1-->3)- . This tetrasaccharide is polymerized and joined by β-1,2 linkages between N-acetyl-D-glucosamine and L-rhamnosyl to form the O-polysaccharide chain
[edit] Proposed functions
N/A
[edit] Antigenic Nature used to produce antibodies
heat-killed S. flexnerf bacteria serotype Y
[edit] Carrier Name
nil
[edit] Conjugation Method
nil
[edit] Antibodies
Mab MASF Y-1
[edit] Antibody type and class
N/A
[edit] Assay System
ELISA, FARR assay
[edit] Cross-reactivity
This Mab bound only to LPS of serotypes 4a and Y. In the glycoconjugate ELISA, MASF Y-1 bound only to the octasaccharide-(cdabcdab') and the decasaccharide-(abcdabcdab') BSA conjugate
[edit] Proposed epitopes
This Mab bound to intrachain determinants
[edit] Proposed Utility
This Mab would help in the delineation of the antigenic stucture of Y O polysaccharide
