PolysacDB O-polysaccharide 9 2212
From DrugPedia: A Wikipedia for Drug discovery
Carbohydrate Name
O-polysaccharide 9
Carbohydrate Class
O-polysaccharide [LPS]
Source Microbe
Salmonella typhi
Basic Structure
LPS O-antigens are formed by the polymerization of a tetrasaccharide repeating unit which is composed of [tyvelose-α[1-->3]-D-mannose-α[1-->3]-L-rhamnose-α[1-->3]-Dα[1-->2]
Proposed functions
It is an important virulence factor. It modulates the host immune defense mechanisms by interference with the normal serum bactericidal activity and/or the process of phagocytosis
Antigenic Nature used to produce antibodies
Heat killed bacteria and purified Vi polysaccharide
Carrier Name
nil
Conjugation Method
nil
Antibodies
Mab MATy-O9
Antibody type and class
IgG3
Assay System
N/A
Cross-reactivity
This Mab cross-reacted with O9 containing dodecasaccharide glycoconjugate which was derived from S. enteritidis SH1262
Proposed epitopes
The dideoxyhexosyl tyvelose residue is the immunodominant epitope
Proposed Utility
This Mab was shown to be a useful serotyping agent by correct identification in slide agglutination tests of 32 clinical isolates of all the S. typhi and other serogroup D salmonellae among a total of 140 bacterial isolates representing eight different Enterobacteriaceae genera tested
