PolysacDB O-polysaccharide 9 2212
From DrugPedia: A Wikipedia for Drug discovery
[edit] Carbohydrate Name
O-polysaccharide 9
[edit] Carbohydrate Class
O-polysaccharide [LPS]
[edit] Source Microbe
Salmonella typhi
[edit] Basic Structure
LPS O-antigens are formed by the polymerization of a tetrasaccharide repeating unit which is composed of [tyvelose-α[1-->3]-D-mannose-α[1-->3]-L-rhamnose-α[1-->3]-Dα[1-->2]
[edit] Proposed functions
It is an important virulence factor. It modulates the host immune defense mechanisms by interference with the normal serum bactericidal activity and/or the process of phagocytosis
[edit] Antigenic Nature used to produce antibodies
Heat killed bacteria and purified Vi polysaccharide
[edit] Carrier Name
nil
[edit] Conjugation Method
nil
[edit] Antibodies
Mab MATy-O9
[edit] Antibody type and class
IgG3
[edit] Assay System
N/A
[edit] Cross-reactivity
This Mab cross-reacted with O9 containing dodecasaccharide glycoconjugate which was derived from S. enteritidis SH1262
[edit] Proposed epitopes
The dideoxyhexosyl tyvelose residue is the immunodominant epitope
[edit] Proposed Utility
This Mab was shown to be a useful serotyping agent by correct identification in slide agglutination tests of 32 clinical isolates of all the S. typhi and other serogroup D salmonellae among a total of 140 bacterial isolates representing eight different Enterobacteriaceae genera tested
