PolysacDB Phenolic glycolipid-I 1742
From DrugPedia: A Wikipedia for Drug discovery
Carbohydrate Name
Phenolic glycolipid-I
Carbohydrate Class
Miscellaneous
Source Microbe
Mycobacterium leprae
Basic Structure
Phenolic glycolipid-1 is a M. leprae-specific antigen that contains a unique trisaccharide, 3,6-di-O-methyl-β-D-glucopyranosyl-(1-->4)-2,3-di-O-methyl-α-L-rhamnopyranosyl-(1-->2)-3-O-methyl-α-L-rhamnopyranose
Proposed functions
It has been widely used for the serodiagnosis of leprosy and has been implicated in the pathogenesis of leprosy
Antigenic Nature used to produce antibodies
Whole cells
Carrier Name
nil
Conjugation Method
nil
Antibodies
Polysera
Antibody type and class
IgM
Assay System
ELISA
Cross-reactivity
The antisera cross-reacted withserovars 5, 12, 18, 20, 23, 24, and 28 of M. avium-M. intracellulare-M. scrofulaceum serocomplex
Proposed epitopes
The trisaccharide appendages of the phenolic glycolipids seemed to be a part of the epitope
Proposed Utility
A specific assay for IgM activity to the specific M. leprae glycolipid, particularly in the preclinical state of the lepromatous form of the disease, may enable earlier chemotherapy and thereby prevent deformity and eliminate the infectious reservoir
