PolysacDB Phenolic glycolipid-I 1742
From DrugPedia: A Wikipedia for Drug discovery
[edit] Carbohydrate Name
Phenolic glycolipid-I
[edit] Carbohydrate Class
Miscellaneous
[edit] Source Microbe
Mycobacterium leprae
[edit] Basic Structure
Phenolic glycolipid-1 is a M. leprae-specific antigen that contains a unique trisaccharide, 3,6-di-O-methyl-β-D-glucopyranosyl-(1-->4)-2,3-di-O-methyl-α-L-rhamnopyranosyl-(1-->2)-3-O-methyl-α-L-rhamnopyranose
[edit] Proposed functions
It has been widely used for the serodiagnosis of leprosy and has been implicated in the pathogenesis of leprosy
[edit] Antigenic Nature used to produce antibodies
Whole cells
[edit] Carrier Name
nil
[edit] Conjugation Method
nil
[edit] Antibodies
Polysera
[edit] Antibody type and class
IgM
[edit] Assay System
ELISA
[edit] Cross-reactivity
The antisera cross-reacted withserovars 5, 12, 18, 20, 23, 24, and 28 of M. avium-M. intracellulare-M. scrofulaceum serocomplex
[edit] Proposed epitopes
The trisaccharide appendages of the phenolic glycolipids seemed to be a part of the epitope
[edit] Proposed Utility
A specific assay for IgM activity to the specific M. leprae glycolipid, particularly in the preclinical state of the lepromatous form of the disease, may enable earlier chemotherapy and thereby prevent deformity and eliminate the infectious reservoir
