PolysacDB N-propionylated group B meningococcal polysaccharide 1578

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Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

[edit] Carbohydrate Name

N-propionylated group B meningococcal polysaccharide

[edit] Carbohydrate Class

Capsular polysaccharide

[edit] Source Microbe

Meningococci group B

[edit] Basic Structure

It is a homopolymer of α(2-->8) sialic acid

[edit] Proposed functions

This capsular polysaccharide is an important virulence determinant. Serum antibodies to the group B polysaccharide confers protection against disease by activating complement-mediated bacteriolysis and/or opsonization. It leads to immunologic tolerance induced by prenatal exposure to host polysialyated glycoproteins

[edit] Antigenic Nature used to produce antibodies

Glycoconjugates

[edit] Carrier Name

Tetanus toxoid

[edit] Conjugation Method

nil

[edit] Antibodies

Polysera

[edit] Antibody type and class

N/A

[edit] Assay System

Radioactive binding inhibition assay, ELISA, Bactericidal assay

[edit] Cross-reactivity

This antisera cross-reacted with capsular polysaccharide of E. coli K1

[edit] Proposed epitopes

N/A

[edit] Proposed Utility

This antisera was bactericidal for Group B meningococci

[edit] Weblink

PubMed

[edit] External Links

• Link to PolysacDB database