PolysacDB N-propionylated group B meningococcal polysaccharide 1578
From DrugPedia: A Wikipedia for Drug discovery
[edit] Carbohydrate Name
N-propionylated group B meningococcal polysaccharide
[edit] Carbohydrate Class
Capsular polysaccharide
[edit] Source Microbe
Meningococci group B
[edit] Basic Structure
It is a homopolymer of α(2-->8) sialic acid
[edit] Proposed functions
This capsular polysaccharide is an important virulence determinant. Serum antibodies to the group B polysaccharide confers protection against disease by activating complement-mediated bacteriolysis and/or opsonization. It leads to immunologic tolerance induced by prenatal exposure to host polysialyated glycoproteins
[edit] Antigenic Nature used to produce antibodies
Glycoconjugates
[edit] Carrier Name
Tetanus toxoid
[edit] Conjugation Method
nil
[edit] Antibodies
Polysera
[edit] Antibody type and class
N/A
[edit] Assay System
Radioactive binding inhibition assay, ELISA, Bactericidal assay
[edit] Cross-reactivity
This antisera cross-reacted with capsular polysaccharide of E. coli K1
[edit] Proposed epitopes
N/A
[edit] Proposed Utility
This antisera was bactericidal for Group B meningococci
