PolysacDB N-propionylated group B meningococcal polysaccharide 1578

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Contents

Carbohydrate Name

N-propionylated group B meningococcal polysaccharide

Carbohydrate Class

Capsular polysaccharide

Source Microbe

Meningococci group B

Basic Structure

It is a homopolymer of α(2-->8) sialic acid


Proposed functions

This capsular polysaccharide is an important virulence determinant. Serum antibodies to the group B polysaccharide confers protection against disease by activating complement-mediated bacteriolysis and/or opsonization. It leads to immunologic tolerance induced by prenatal exposure to host polysialyated glycoproteins

Antigenic Nature used to produce antibodies

Glycoconjugates

Carrier Name

Tetanus toxoid

Conjugation Method

nil

Antibodies

Polysera

Antibody type and class

N/A

Assay System

Radioactive binding inhibition assay, ELISA, Bactericidal assay

Cross-reactivity

This antisera cross-reacted with capsular polysaccharide of E. coli K1

Proposed epitopes

N/A

Proposed Utility

This antisera was bactericidal for Group B meningococci

Weblink

PubMed

External Links

Retrieved from "http://277988.efsst.group/drugpedia/index.php/PolysacDB_N-propionylated_group_B_meningococcal_polysaccharide_1578"