PolysacDB Glucurunoxylomannan 1496

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

[edit] Carbohydrate Name

Glucurunoxylomannan

[edit] Carbohydrate Class

Miscellaneous

[edit] Source Microbe

Cryptococcus neoformans Serotype A [strain 24064]

[edit] Basic Structure

The major component of C. neoformans capsular polysaccharide is glucurunoxylomannan [GXM] consisting of an unbranched mannose backbone substituted with xylose, glucuronic acid and O-acetyl residues

[edit] Proposed functions

C. neoformans has a large polysaccharide capsule that is a determinant of virulence. The capsular polysaccharide causes immunologic paralysis and inhibits phagocytosis by macrophages. Soluble C. neoformans capsular polysaccharide enhances human immunodeficiency virus [HIV] infection in cultured cells, suggesting a new pathogenic role in AIDS

[edit] Antigenic Nature used to produce antibodies

Glycoconjugates

[edit] Carrier Name

Tetanus toxoid

[edit] Conjugation Method

GXM was conjugated to tetanus toxoid using CDAP precipitation

[edit] Antibodies

Polysera

[edit] Antibody type and class

IgG [predominantly IgG1]

[edit] Assay System

ELISA

[edit] Cross-reactivity

This antibody cross-reacted with Serotype D strains

[edit] Proposed epitopes

N/A

[edit] Proposed Utility

N/A

[edit] Weblink

PubMed

[edit] External Links

• Link to PolysacDB database