PolysacDB Glucurunoxylomannan 1496
From DrugPedia: A Wikipedia for Drug discovery
[edit] Carbohydrate Name
Glucurunoxylomannan
[edit] Carbohydrate Class
Miscellaneous
[edit] Source Microbe
Cryptococcus neoformans Serotype A [strain 24064]
[edit] Basic Structure
The major component of C. neoformans capsular polysaccharide is glucurunoxylomannan [GXM] consisting of an unbranched mannose backbone substituted with xylose, glucuronic acid and O-acetyl residues
[edit] Proposed functions
C. neoformans has a large polysaccharide capsule that is a determinant of virulence. The capsular polysaccharide causes immunologic paralysis and inhibits phagocytosis by macrophages. Soluble C. neoformans capsular polysaccharide enhances human immunodeficiency virus [HIV] infection in cultured cells, suggesting a new pathogenic role in AIDS
[edit] Antigenic Nature used to produce antibodies
Glycoconjugates
[edit] Carrier Name
Tetanus toxoid
[edit] Conjugation Method
GXM was conjugated to tetanus toxoid using CDAP precipitation
[edit] Antibodies
Polysera
[edit] Antibody type and class
IgG [predominantly IgG1]
[edit] Assay System
ELISA
[edit] Cross-reactivity
This antibody cross-reacted with Serotype D strains
[edit] Proposed epitopes
N/A
[edit] Proposed Utility
N/A
