PolysacDB Glucomannoprotein 1263

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

[edit] Carbohydrate Name

Glucomannoprotein

[edit] Carbohydrate Class

Miscellaneous

[edit] Source Microbe

Candida albicans serotype A

[edit] Basic Structure

N/A

[edit] Proposed functions

N/A

[edit] Antigenic Nature used to produce antibodies

glucomannoprotein-rich antigenic extract (GMP)

[edit] Carrier Name

nil

[edit] Conjugation Method

nil

[edit] Antibodies

Mab AF-1

[edit] Antibody type and class

IgM

[edit] Assay System

ELISA, immunofluorescence and slide agglutination tests

[edit] Cross-reactivity

This Mab cross-reacted with C. albicans serotypes A and B, C. tropicalis, C. guilliermondii and C. viswanathii, but did not cross-react with C. krusei, C. parapsilosis, C. kefyr (pseudotropicalis) and T. Glabrata

[edit] Proposed epitopes

The epitope was proposed to consist of mannan residues

[edit] Proposed Utility

This Mab had strong agglutination properties for Candida species. This Mab helped in the identification of new polysaccharide epitopes on the cell wall of pathogenic Candida species.

[edit] Weblink

PubMed

[edit] External Links

• Link to PolysacDB database