PolysacDB Glucomannoprotein 1263
From DrugPedia: A Wikipedia for Drug discovery
[edit] Carbohydrate Name
Glucomannoprotein
[edit] Carbohydrate Class
Miscellaneous
[edit] Source Microbe
Candida albicans serotype A
[edit] Basic Structure
N/A
[edit] Proposed functions
N/A
[edit] Antigenic Nature used to produce antibodies
glucomannoprotein-rich antigenic extract (GMP)
[edit] Carrier Name
nil
[edit] Conjugation Method
nil
[edit] Antibodies
Mab AF-1
[edit] Antibody type and class
IgM
[edit] Assay System
ELISA, immunofluorescence and slide agglutination tests
[edit] Cross-reactivity
This Mab cross-reacted with C. albicans serotypes A and B, C. tropicalis, C. guilliermondii and C. viswanathii, but did not cross-react with C. krusei, C. parapsilosis, C. kefyr (pseudotropicalis) and T. Glabrata
[edit] Proposed epitopes
The epitope was proposed to consist of mannan residues
[edit] Proposed Utility
This Mab had strong agglutination properties for Candida species. This Mab helped in the identification of new polysaccharide epitopes on the cell wall of pathogenic Candida species.
