CarboDB Glycosphingolipid antigen 1535

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

[edit] Carbohydrate Name

Glycosphingolipid antigen

[edit] Carbohydrate Class

Miscellaneous

[edit] Source Microbe

Leishmania amazonensis

[edit] Basic Structure

The structure of the glycosphingolipid is as follows : &alpha-Neup5Ac-(2-->3)-β-D-Galp-(1-->3)-β-D-GalpNAc-(1-->4)-β-D-Galp [branched to α-Neup5Ac-(2-->3)-] -(1-->4)-β-D-Glcp-(1-?)-CER-(?--/Ceramide/

[edit] Proposed functions

N/A

[edit] Antigenic Nature used to produce antibodies

L. amazonensis amastigotes

[edit] Carrier Name

nil

[edit] Conjugation Method

nil

[edit] Antibodies

Mab 1C3

[edit] Antibody type and class

N/A

[edit] Assay System

Indirect immunofluorescence, immunoblotting and immunoprecipitation

[edit] Cross-reactivity

This Mab reacted with amastigotes and cross-reacts with gp63 from L. amazonensis promastigotes

[edit] Proposed epitopes

ceramide-N-acetylneuraminic acid (GM1) and ceramide-N-tetrose-di-acetylneuraminic acid (GDla) residues seemed to be a part of the epitope

[edit] Proposed Utility

MAb 1C3 Fab fragments inhibited about 60% of the penetration of amastigotes into macrophages

[edit] Weblink

PubMed Central

[edit] External Links

• BCSDB Structural Detail

• Link to CarboDB database