CarboDB Glycosphingolipid antigen 1535
From DrugPedia: A Wikipedia for Drug discovery
[edit] Carbohydrate Name
Glycosphingolipid antigen
[edit] Carbohydrate Class
Miscellaneous
[edit] Source Microbe
Leishmania amazonensis
[edit] Basic Structure
The structure of the glycosphingolipid is as follows : &alpha-Neup5Ac-(2-->3)-β-D-Galp-(1-->3)-β-D-GalpNAc-(1-->4)-β-D-Galp [branched to α-Neup5Ac-(2-->3)-] -(1-->4)-β-D-Glcp-(1-?)-CER-(?--/Ceramide/
[edit] Proposed functions
N/A
[edit] Antigenic Nature used to produce antibodies
L. amazonensis amastigotes
[edit] Carrier Name
nil
[edit] Conjugation Method
nil
[edit] Antibodies
Mab 1C3
[edit] Antibody type and class
N/A
[edit] Assay System
Indirect immunofluorescence, immunoblotting and immunoprecipitation
[edit] Cross-reactivity
This Mab reacted with amastigotes and cross-reacts with gp63 from L. amazonensis promastigotes
[edit] Proposed epitopes
ceramide-N-acetylneuraminic acid (GM1) and ceramide-N-tetrose-di-acetylneuraminic acid (GDla) residues seemed to be a part of the epitope
[edit] Proposed Utility
MAb 1C3 Fab fragments inhibited about 60% of the penetration of amastigotes into macrophages
