CarboDB Core oligosaccharide 1233

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

Carbohydrate Name

Core oligosaccharide

Carbohydrate Class

Core oligosaccharide [LPS]

Source Microbe

Brucella abortus S19

Basic Structure

Core oligosaccharide is composed of mannose, glucose, 2-amino-2,6-dideoxyglucose (quinovosamine), 2-amino-2-deoxyglucose (GlcN),3-deoxy-D-manno-2-octulosonic acid (KDO), and unidentified sugars. The core is linked to the lipid A, which in contrast to most LPS studied, contains both GlcN and 2,3- diamino-2,3-dideoxyglucose (GlcN3N) as backbone sugars and amide- and ester-linked long-chain saturated (C16:0 to C18:0) and hydroxylated (3-OH-C12:0, to 29-OH-C30:0) fatty acids

Proposed functions

N/A

Antigenic Nature used to produce antibodies

acetone-killed B. abortus S19 cells

Carrier Name

nil

Conjugation Method

nil

Antibodies

Mab Baro-2

Antibody type and class

IgM

Assay System

Enzyme Immunoassay,immunoblotting

Cross-reactivity

the Baro-2 MAb showed reactivity against LPS from E. coli Re, S. minnesota Re, S. typhimurium Rd2, and S. typhimurium Rdl

Proposed epitopes

3-deoxy-D-manno-2-octulosonic acid (KDO)seems to be an important part of the epitope

Proposed Utility

This Mab may help in the elucidation of epitopic distribution of Brucella abortus LPS

Weblink

PubMed Central

External Links

• Link to CarboDB database