CarboDB Core oligosaccharide 1233
From DrugPedia: A Wikipedia for Drug discovery
[edit] Carbohydrate Name
Core oligosaccharide
[edit] Carbohydrate Class
Core oligosaccharide [LPS]
[edit] Source Microbe
Brucella abortus S19
[edit] Basic Structure
Core oligosaccharide is composed of mannose, glucose, 2-amino-2,6-dideoxyglucose (quinovosamine), 2-amino-2-deoxyglucose (GlcN),3-deoxy-D-manno-2-octulosonic acid (KDO), and unidentified sugars. The core is linked to the lipid A, which in contrast to most LPS studied, contains both GlcN and 2,3- diamino-2,3-dideoxyglucose (GlcN3N) as backbone sugars and amide- and ester-linked long-chain saturated (C16:0 to C18:0) and hydroxylated (3-OH-C12:0, to 29-OH-C30:0) fatty acids
[edit] Proposed functions
N/A
[edit] Antigenic Nature used to produce antibodies
acetone-killed B. abortus S19 cells
[edit] Carrier Name
nil
[edit] Conjugation Method
nil
[edit] Antibodies
Mab Baro-2
[edit] Antibody type and class
IgM
[edit] Assay System
Enzyme Immunoassay,immunoblotting
[edit] Cross-reactivity
the Baro-2 MAb showed reactivity against LPS from E. coli Re, S. minnesota Re, S. typhimurium Rd2, and S. typhimurium Rdl
[edit] Proposed epitopes
3-deoxy-D-manno-2-octulosonic acid (KDO)seems to be an important part of the epitope
[edit] Proposed Utility
This Mab may help in the elucidation of epitopic distribution of Brucella abortus LPS
