CarboDB Galactomannan 1037

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

Carbohydrate Name

Galactomannan

Carbohydrate Class

Miscellaneous

Source Microbe

Aspergillus fumigatus

Basic Structure

Galactomannan is composed of a branched core containing α(1-->2)- and α(1-->6)-linked mannose, with β(1-->5)galactofuranose and/or β(1-->4)galactopyranose moieties linked linearly in side chains terminated by galactofuranose nonreducing end units

Proposed functions

Galactomannan is a major cell wall component in Aspergillusspecies and can also be secreted into the medium as a component of the exoantigen. The galactomannan is immunogenic and polyclonal antibodies against it have been used in antigen detection for the diagnosis of invasive aspergillosis, and in the detection of fungal contamination in foodstuffs

Antigenic Nature used to produce antibodies

Formalinized spores of A. fumigatus.

Carrier Name

N/A

Conjugation Method

N/A

Antibodies

Mab EB-A2

Antibody type and class

IgM

Assay System

Indirect and Competitive ELISA

Cross-reactivity

This antibody cross-reacted to P. digitatum and Penicillium marneffei speices.

Proposed epitopes

3(1-->5)galactofuranose residues of galactomannan

Proposed Utility

EB-A2 has been used to detect circulating antigen in the serum of patients with invasive aspergillosis by ELISA inhibition. The sensitivity (95%), specificity (100%), positive predictive value (100%), and negative predictive value (99%)of the ELISA

Weblink

PubMed Central

External Links

• Link to CarboDB database