CarboDB Galactomannan 1037
From DrugPedia: A Wikipedia for Drug discovery
[edit] Carbohydrate Name
Galactomannan
[edit] Carbohydrate Class
Miscellaneous
[edit] Source Microbe
Aspergillus fumigatus
[edit] Basic Structure
Galactomannan is composed of a branched core containing α(1-->2)- and α(1-->6)-linked mannose, with β(1-->5)galactofuranose and/or β(1-->4)galactopyranose moieties linked linearly in side chains terminated by galactofuranose nonreducing end units
[edit] Proposed functions
Galactomannan is a major cell wall component in Aspergillusspecies and can also be secreted into the medium as a component of the exoantigen. The galactomannan is immunogenic and polyclonal antibodies against it have been used in antigen detection for the diagnosis of invasive aspergillosis, and in the detection of fungal contamination in foodstuffs
[edit] Antigenic Nature used to produce antibodies
Formalinized spores of A. fumigatus.
[edit] Carrier Name
N/A
[edit] Conjugation Method
N/A
[edit] Antibodies
Mab EB-A2
[edit] Antibody type and class
IgM
[edit] Assay System
Indirect and Competitive ELISA
[edit] Cross-reactivity
This antibody cross-reacted to P. digitatum and Penicillium marneffei speices.
[edit] Proposed epitopes
3(1-->5)galactofuranose residues of galactomannan
[edit] Proposed Utility
EB-A2 has been used to detect circulating antigen in the serum of patients with invasive aspergillosis by ELISA inhibition. The sensitivity (95%), specificity (100%), positive predictive value (100%), and negative predictive value (99%)of the ELISA
