Corticosterone
From DrugPedia: A Wikipedia for Drug discovery
| Corticosterone
| |
| Systematic (IUPAC) name | |
| (8S,9S,10R,11S,13S,14S,17S)-11-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one | |
| Identifiers | |
| CAS number | |
| ATC code | ? |
| PubChem | |
| Chemical data | |
| Formula | C21H30O4 |
| Mol. mass | 346.46 |
| SMILES | & |
| Synonyms | 17-Deoxycortisol |
| Physical data | |
| Melt. point | 181 °C |
| Solubility in water | 199 mg/L at 25oC EXP mg/mL |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | ? |
| Half life | ? |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
? |
| Legal status | |
| Routes | ? |
An adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid. (From Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1437).Corticosterone is a 21 carbon steroid hormone of the corticosteroid type produced in the cortex of the adrenal glands.
Contents |
Physiochemical Properties
Melting Point
181 deg C EXP
log P
1.94
Water Solubility=
199 mg/L 25 EXP Vapor Pressure=== 4.74E-12 mm Hg 25 EST Henry's Law Constant=== 3.70E-10 atm-m3/mole 25 EST |Atmospheric OH Rate Constant=== 1.16E-10 cm3/molecule-sec 25 EST
Functions
In many species, including rodents, corticosterone is the principal glucocorticoid, involved in regulation of fuel metabolism, immune reactions, and stress responses.
However, in humans, corticosterone is produced primarily in the zona fasciculata of the adrenal cortex. It has only weak glucocorticoid and mineralocorticoid potencies in humans and is important mainly as an intermediate in the steroidogenic pathway from pregnenolone to aldosterone. Corticosterone is converted to aldosterone by aldosterone synthase, found only in the mitochondria of glomerulosa cells. Glomerulosa cells are found in the Zona glomerulosa, which is the most superficial region of endocrine cells in the adrenal cortex.
