20-alpha-dihydroprogesterone

From DrugPedia: A Wikipedia for Drug discovery

Dihydrogesterone Pubchem(8956)

A biologically active 20-alpha-reduced metabolite of PROGESTERONE. It is converted from progesterone to 20-alpha-hydroxypregn-4-en-3-one by the 20-ALPHA-HYDROXYSTEROID DEHYDROGENASE in the CORPUS LUTEUM and the PLACENTA.

KEGG Pathway(C04042,C03965)

• C21-Steroid hormone metabolism

|24630 |1MRQ |Couture JF, Legrand P, Cantin L, Luu-The V, Labrie F, Breton RHuman 20alpha-hydroxysteroid dehydrogenase: crystallographic and site-directed mutagenesis studies lead to the identification of an alternative binding site for C21-steroidsJ. Mol. Biol. v331, p.593-604 |- |}