PolysacDB Glucomannoprotein 1263

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

Carbohydrate Name

Glucomannoprotein

Carbohydrate Class

Miscellaneous

Source Microbe

Candida albicans serotype A

Basic Structure

N/A

Proposed functions

N/A

Antigenic Nature used to produce antibodies

glucomannoprotein-rich antigenic extract (GMP)

Carrier Name

nil

Conjugation Method

nil

Antibodies

Mab AF-1

Antibody type and class

IgM

Assay System

ELISA, immunofluorescence and slide agglutination tests

Cross-reactivity

This Mab cross-reacted with C. albicans serotypes A and B, C. tropicalis, C. guilliermondii and C. viswanathii, but did not cross-react with C. krusei, C. parapsilosis, C. kefyr (pseudotropicalis) and T. Glabrata

Proposed epitopes

The epitope was proposed to consist of mannan residues

Proposed Utility

This Mab had strong agglutination properties for Candida species. This Mab helped in the identification of new polysaccharide epitopes on the cell wall of pathogenic Candida species.

Weblink

PubMed

External Links

• Link to PolysacDB database