PolysacDB Lipopolysaccharide 1046
From DrugPedia: A Wikipedia for Drug discovery
Carbohydrate Name
Lipopolysaccharide
Carbohydrate Class
Lipopolysaccharide
Source Microbe
Salmonella typhimurium SR-11
Basic Structure
LPS is composed of three parts: (1) lipid A, (2) core polysaccharide, and (3) O antigen. The lipid A region contains two glucosamine sugar derivatives, each with three fatty acids and phosphate or pyrophosphate attached. The core polysaccharide has KDO and attached to lipid A. The side chain O is small polysaccharide chain extending outward from the core, it has several peculiar sugars and varies in composition between bacterial strains.
Proposed functions
LPS is most unusual constituents of outer membrane. It plays important role in host defence avoidance. LPS contributes to the negative charge of the bacterial surface. Lipid A is often toxic and act as endotoxin
Antigenic Nature used to produce antibodies
Live S.typhimurium SR cells.
Carrier Name
nil
Conjugation Method
nil
Antibodies
Polysera
Antibody type and class
IgG
Assay System
ELISA Hemaggluttination assay
Cross-reactivity
This antibody was cross-reactive with Salmonella typhimurium LT-2, Salmonella typhimurium derby. Salmonella typhimurium dublin, Salmonella enteritidis and Salmonella paratyphi A.
Proposed epitopes
O-polysaccharide
Proposed Utility
This antibody can be used in serological assays to detect the desired antigen.
