PolysacDB Lipopolysaccharide 1046
From DrugPedia: A Wikipedia for Drug discovery
[edit] Carbohydrate Name
Lipopolysaccharide
[edit] Carbohydrate Class
Lipopolysaccharide
[edit] Source Microbe
Salmonella typhimurium SR-11
[edit] Basic Structure
LPS is composed of three parts: (1) lipid A, (2) core polysaccharide, and (3) O antigen. The lipid A region contains two glucosamine sugar derivatives, each with three fatty acids and phosphate or pyrophosphate attached. The core polysaccharide has KDO and attached to lipid A. The side chain O is small polysaccharide chain extending outward from the core, it has several peculiar sugars and varies in composition between bacterial strains.
[edit] Proposed functions
LPS is most unusual constituents of outer membrane. It plays important role in host defence avoidance. LPS contributes to the negative charge of the bacterial surface. Lipid A is often toxic and act as endotoxin
[edit] Antigenic Nature used to produce antibodies
Live S.typhimurium SR cells.
[edit] Carrier Name
nil
[edit] Conjugation Method
nil
[edit] Antibodies
Polysera
[edit] Antibody type and class
IgG
[edit] Assay System
ELISA Hemaggluttination assay
[edit] Cross-reactivity
This antibody was cross-reactive with Salmonella typhimurium LT-2, Salmonella typhimurium derby. Salmonella typhimurium dublin, Salmonella enteritidis and Salmonella paratyphi A.
[edit] Proposed epitopes
O-polysaccharide
[edit] Proposed Utility
This antibody can be used in serological assays to detect the desired antigen.
