CarboDB Lipopolysaccharide 2209
From DrugPedia: A Wikipedia for Drug discovery
Carbohydrate Name
Lipopolysaccharide
Carbohydrate Class
Lipopolysaccharide
Source Microbe
Salmonella enteritidis
Basic Structure
LPS is a complex macromolecule composed of the biologically active lipid A moiety, covalently attached core oligosaccharide, and distally linked polysaccharide O-side chain. The O-antigen part consists of the following residues : -2)-α-D-Manp [branched to α-Tyvp-(1-->3)] -(1-->4)-α-L-Rhap-(1-->3)-α-D-Galp-(1-
Proposed functions
LPS plays an important virulence role based on its antiphagocytic and endotoxic properties
Antigenic Nature used to produce antibodies
live attenuated mutant strain of Salmonella typhimurium
Carrier Name
nil
Conjugation Method
nil
Antibodies
Mab 8aC10
Antibody type and class
N/A
Assay System
ELISA, immunoblotting, passive hemagglutination (PHA), passive hemolysis and agglutination tests
Cross-reactivity
The MAb reacted only with lipopolysaccharides (LPS) of Salmonella strains from group O:4 (B), expressing O:5 antigen. The MAb agglutinated in addition Salmonella strains with O:8 antigen from group C(2)-C(3) but did not react with purified LPS
Proposed epitopes
This Mab is directed to Salmonella O:5 antigen of the LPS. The epitope is possibly localized onto O-acetyl-abequose and abequose residues bound with a α-1-->3 linkage to the basic polysaccharide backbone of Salmonella LPS with O:5 and O:8 antigen respectively
Proposed Utility
This Mab can be used for identification of Salmonella strains having O:5 LPS
