Corticosterone

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-	'''CORTICOSTERONE'''
-	Pubchem(5753)
-	An adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid. (From Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1437).Corticosterone is a 21 carbon [[steroid hormone]] of the [[corticosteroid]] type produced in the cortex of the [[adrenal gland]]s.
-	'''KEGG Pathway'''(C02140)	+	<table align='right' border=1>
-	*C21-Steroid hormone metabolism	+	<tr><td>
-	{| border="1;width:100%; height:200px;style=text-align:center"	+	<jmol><jmolApplet>
-	|+'''List of PDB files having Corticosterone as a Ligand:'''	+	<size>200</size>
-	|-	+	<script>spin on;color atoms amino;</script>
-	! style="background:brown; color:white" |MMDB ID	+	<uploadedFileContents>NPH132.SDF</uploadedFileContents>
-	! style="background:brown; color:white" |PDB ID	+	<color>black</color>
-	! style="background:brown; color:white" |Reference	+	</jmolApplet>
-	|-	+	</jmol>
-	|33346	+	</td></tr></table>
-	|1Y5R	+	==Description==
-	|Zhang J, Osslund TD, Plant MH, Clogston CL, Nybo RE, Xiong F, Delaney JM, Jordan SRCrystal structure of murine 11 beta-hydroxysteroid dehydrogenase 1: an important therapeutic target for diabetesBiochemistry v44, p.6948-6957	+	An adrenocortical steroid that has modest but significant activities  as a mineralocorticoid and a glucocorticoid. (From Goodman and  Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1437)
-	|-	+	==General Properties==
-	|}	+
-	{| border="1;width:100%; height:200px;style=text-align:center"	+
-	|+'''Physiochemical properties of Corticosterone:'''	+
-	|-	+
-	! style="background:brown; color:white" |Physical Property	+
-	! style="background:brown; color:white" |Value	+
-	! style="background:brown; color:white" |Units	+
-	! style="background:brown; color:white" |Temp (deg C)	+
-	! style="background:brown; color:white" |Source	+
-	|-	+
-	|Melting Point	+
-	|181	+
-	|deg C	+
-	|	+
-	|EXP	+
-	|-	+
-	|log P (octanol-water)	+
-	|1.94	+
-	|(none)	+
-	|	+
-	|EXP	+
-	|-	+
-	|Water Solubility	+
-	|199	+
-	|mg/L	+
-	|25	+
-	|EXP	+
-	|-	+
-	|Vapor Pressure	+
-	|4.74E-12	+
-	|mm Hg	+
-	|25	+
-	|EST	+
-	|-	+
-	|Henry's Law Constant	+
-	|3.70E-10	+
-	|atm-m3/mole	+
-	|25	+
-	|EST	+
-	|-	+
-	|Atmospheric OH Rate Constant	+
-	|1.16E-10	+
-	|cm3/molecule-sec	+
-	|25	+
-	|EST	+
-	|-	+
-	|}	+
-	==Functions==	+
-	In many species, including [[rodent]]s, corticosterone is the principal [[glucocorticoid]], involved in regulation of fuel [[metabolism]], [[immune]] reactions, and [[stress (medicine)|stress]] responses.	+
-	However, in [[humans]], corticosterone is produced primarily in the [[zona fasciculata]] of the [[adrenal cortex]]. It has only weak [[glucocorticoid]] and [[mineralocorticoid]] potencies in humans and is important mainly as an intermediate in the [[steroidogenic pathway]] from [[pregnenolone]] to [[aldosterone]]. Corticosterone is converted to aldosterone by aldosterone synthase, found only in the mitochondria of glomerulosa cells. Glomerulosa cells are found in the [[Zona glomerulosa]], which is the most superficial region of endocrine cells in the [[adrenal cortex]].	+	<b>*Molecular Weight</b>
		+
		+	346.46
		+
		+	<b>*Molecular Formula</b>
		+
		+	C<sub>2</sub><sub>1</sub>H<sub>3</sub><sub>0</sub>O<sub>4</sub>
		+
		+	<b>*IUPAC NAME</b>
		+
		+	(8S,9S,10R,11S,13S,14S,17S)-11-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
		+
		+	<b>*Canonical Smiles</b>
		+
		+	CC12CCC(=O)C=C1CCC3C2C(CC4(C3CCC4C(=O)CO)C)O
		+
		+	<b>*Isomeric Smiles</b>
		+
		+	C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2[C@H](C[C@]4([C@H]3CC[C@@H]4C(=O)CO)C)O
		+
		+
		+	==PhysioChemical Properties==
		+
		+	<b>*Melting Point</b>
		+
		+	181(EXP)
		+
		+	<b>*LogP</b>
		+
		+	1.94(EXP)
		+
		+	<b>*Water Solubility</b>
		+
		+	199(EXP) at 25C
		+
		+	==External Links==
		+	*[http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=5753]Pubchem
		+	*[http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1Y5R]]1Y5R,
		+	*[http://www.genome.jp/dbget-bin/www_bget?compound+C02140]]KEGG Compound
		+	*[http://www.hmdb.ca/metabolites/HMDB01547]Human Metabolome DataBase
		+
		+
		+	[[Categories:Hormones]]

---

Revision as of 00:00, 15 January 2001

Contents 1 Description 2 General Properties 3 PhysioChemical Properties 4 External Links

Description

An adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid. (From Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1437)

General Properties

*Molecular Weight

346.46

*Molecular Formula

C₂₁H₃₀O₄

*IUPAC NAME

(8S,9S,10R,11S,13S,14S,17S)-11-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one

*Canonical Smiles

CC12CCC(=O)C=C1CCC3C2C(CC4(C3CCC4C(=O)CO)C)O

*Isomeric Smiles

C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2[C@H](C[C@]4([C@H]3CC[C@@H]4C(=O)CO)C)O

PhysioChemical Properties

*Melting Point

181(EXP)

*LogP

1.94(EXP)

*Water Solubility

199(EXP) at 25C

External Links

• [1]Pubchem
• [2]]1Y5R,
• [3]]KEGG Compound
• [4]Human Metabolome DataBase

Categories:Hormones