11-Deoxycortisol

From DrugPedia: A Wikipedia for Drug discovery

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Revision as of 08:56, 1 November 2008

Cortexolone Pubchem(440707)

17,21-Dihydroxypregn-4-ene-3,20-dione. A 17-hydroxycorticosteroid with glucocorticoid and anti-inflammatory activities.

KEGG Pathway(C05488,D03595)

• C21-Steroid hormone metabolism

Activity Anti-inflammatory

Physical Property Value Units Temp (deg C) Source |Melting Point |215 |deg C | |EXP |- |log P (octanol-water) |3.08 |(none) | |EXP |- |Water Solubility |15.2 |mg/L |25 |EST |- |Vapor Pressure |9.49E-12 |mm Hg |25 |EST |- |Henry's Law Constant |1.58E-06 |atm-m3/mole |25 |EST |- |Atmospheric OH Rate Constant |1.05E-10 |cm3/molecule-sec |25 |EST |- |} Organism Test Type Route Reported Dose (Normalized Dose) Effect Source |mouse |LD50 |intravenous |100mg/kg (100mg/kg) |U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#04684, |}