11-Deoxycortisol
From DrugPedia: A Wikipedia for Drug discovery
Cortexolone Pubchem(440707)
17,21-Dihydroxypregn-4-ene-3,20-dione. A 17-hydroxycorticosteroid with glucocorticoid and anti-inflammatory activities.11-Deoxycortisol (or cortodoxone) is a steroid, and an immediate precursor to the production of cortisol. It can be synthesized from 17-hydroxyprogesterone.
KEGG Pathway(C05488,D03595)
- C21-Steroid hormone metabolism
Activity Anti-inflammatory
| Physical Property | Value | Units | Temp (deg C) | Source |
|---|---|---|---|---|
| Melting Point | 215 | deg C | EXP | |
| log P (octanol-water) | 3.08 | (none) | EXP | |
| Water Solubility | 15.2 | mg/L | 25 | EST |
| Vapor Pressure | 9.49E-12 | mm Hg | 25 | EST |
| Henry's Law Constant | 1.58E-06 | atm-m3/mole | 25 | EST |
| Atmospheric OH Rate Constant | 1.05E-10 | cm3/molecule-sec | 25 | EST |
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intravenous | 100mg/kg (100mg/kg) | U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#04684, |
