PolysacDB Glucurunoxylomannan 2636
From DrugPedia: A Wikipedia for Drug discovery
(Difference between revisions)
Revision as of 06:14, 8 April 2010
Carbohydrate Name
Glucurunoxylomannan
Carbohydrate Class
Miscellaneous
Source Microbe
Cryptococcus neoformans Serotype A
Basic Structure
A linear α(1-->3)- linked mannan backbone singly substituted with non-reducing β(1-->2) xylose and β(1-->2) glucuronic acid side branches ; O-acetyl groups are present at C-6 of the mannosyl residues
Proposed functions
Antiphagocytic ; an important virulence factor
Antigenic Nature used to produce antibodies
Glycoconjugates
Carrier Name
Tetanus toxoid
Conjugation Method
Conjugated using CDAP chemistry
Antibodies
Mab 13F1
Antibody type and class
IgM
Assay System
ELISA
Cross-reactivity
This antibody cross-reacted with Serotype A,B,C and D serotypes
Proposed epitopes
This Mab did not bind de-O-acetylated GXM suggesting that acetylated residues form an important part of the epitope
Proposed Utility
This antibody was used to decipher and differentiate the serum antibody response of autoimmune mice as compared to normal mice
