PolysacDB Lipopolysaccharide 2206

From DrugPedia: A Wikipedia for Drug discovery

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Revision as of 06:12, 8 April 2010

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

Carbohydrate Name

Lipopolysaccharide

Carbohydrate Class

Lipopolysaccharide

Source Microbe

Serogroup D Salmonella

Basic Structure

LPS is a complex macromolecule composed of the biologically active lipid A moiety, covalently attached core oligosaccharide, and distally linked polysaccharide O-side chain. The O-antigen part of Salmonella enterica group D LPS is as follows : -2)-α-D-Manp [branched to α-Tyvp-(1-->3)] -(1-->4)-α-L-Rhap-(1-->3)-α-D-Galp [branched to α-D-Glcp-(1-->4)]-(1-

Proposed functions

LPS plays an important virulence role based on its antiphagocytic and endotoxic properties

Antigenic Nature used to produce antibodies

Whole cells

Carrier Name

nil

Conjugation Method

nil

Antibodies

Mab SA:5D12A

Antibody type and class

N/A

Assay System

ELISA

Cross-reactivity

This Mab reacted with Salmonella serogroups A-E and a rough strain of S. cholerae-suis

Proposed epitopes

N/A

Proposed Utility

The usefulness of Mabs can be generated for diagnostic and protective purposes

Weblink

PubMed

External Links

• Link to PolysacDB database